The effect of phytic acid on enzymatic degradation of dentin

We evaluated the effect of phytic acid on matrix metalloproteinase (MMP)- or cysteine cathepsin (CC)-mediated dentin degradation. Demineralized beams were divided into five groups (n = 12) and treated with 1%, 2%, 3% 37% phosphoric acid. Untreated demineralized served as controls. After incubation for 1 3 wk, dry mass loss was determined aliquots media analysed cross-linked telopeptide type I collagen (ICTP) fragments MMP-mediated c-terminal (CTX) cathepsin-k-mediated The direct using MMP activity assay. Data repeated-measures anova. ICTP releases 1% 2% treatment statistically significantly lower than those following at wk. CTX release acid-treated wk not different from that untreated control beams, but it beams. Their activities controls they seen Compared to acid, resulted in a reduced dentinal host-derived endogenous enzymatic